Publications

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Multi-Domain Interplay Controls Full-Length TDP-43 Phase Separation and Condensate Dynamics Preprint

Xiao-Fei Ping, Rodrique G. M. Badr, S. Hutten, Xin-Xiang Chen, Lucia Baltz, Mahesh C. Yadav, Jana Höppner, Friederike Schmid, Dorothee Dormann, and L. Stelzl

Citation Count: 0
Published: 2026-10-06 in bioRxiv

Phase separation behavior of TDP-43 governs its protein interactome and regulation of alternative splicing Preprint

Yelyzaveta Zadorozhna, Federico Uliana, Emanuele Zippo, Anke Busch, Niklas Kretschmer, Simone Mosna, Y. Suk, Jia-Xuan Chen, Martina Hallegger, Carla Schmidt, L. Stelzl, and Dorothee Dormann

Citation Count: 0
Published: 2026-08-28 in bioRxiv

Biochemical communication with noisy feedback under energy constraints Preprint

Maximilian Gehri, L. Stelzl, and Heinz Koeppl

Citation Count: 0
Published: 2026-07-07 in bioRxiv

Active Learning–Guided Peptide Design for Modulating Condensate Properties upon Recruitment Preprint

K. Gaurav, Rodrique G. M. Badr, Arya Changiarath, Vasileios A. Xenidis, and L. Stelzl

Citation Count: 0
Published: 2026-06-26 in bioRxiv

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, T. Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer-Depoix, K. Landfester, Carla Schmidt, M. Möckel, S. Morsbach, Friederike Schmid, Dorothee Dormann, L. Stelzl, Martin Girard, and E. A. Lemke

Citation Count: 0
Published: 2026-06-26 in Advanced Science

TDP-43 self-assembly is regulated by its disordered NLS-region Preprint

S. Hutten, Emre Pekbilir, Benjamin M. R. Bourgeois, Xiao-Fei Ping, C. Rickert, Nele S. Kuhr, Nora Knabe, Simone Mosna, T. Madl, L. Stelzl, and Dorothee Dormann

Citation Count: 0
Published: 2026-06-09 in bioRxiv

Programmable DNA protonuclei reveal environmental context on protein phase separation

J. Fritzen, Avik Samanta, Nele S. Kuhr, Antonia Preuß, Erin L. Sternburg, L. Stelzl, J. J. Michels, Dorothee Dormann, and Andreas Walther

Citation Count: 1
Published: 2026-05-08 in Nature Communications

Active transport as a mechanism of microphase selection in biomolecular condensates

Le Qiao, Peter Gispert, L. Stelzl, and Friederike Schmid

Citation Count: 2
Published: 2026-04-09 in Physical Review Research

Atomistic simulations reveal sub-µs contact dynamics in MUT-16 condensates Preprint

K. Gaurav, Lucia Baltz, D. J. Páez-Moscoso, R. Ketting, and L. Stelzl

Citation Count: 1
Published: 2026-04-06 in bioRxiv

Proteolytic Control of an Auto-inhibitory Intrinsically Disordered Region Governs Small RNA Selectivity in Argonaute Proteins Preprint

Ida Isolehto, Lizaveta Pshanichnaya, D. J. Páez-Moscoso, M. Mager, Ann-Sophie Seistrup, Jan Schreier, Svenja Hellmann, K. Gaurav, Fridolin Kielisch, Juaxuan Chen, L. Stelzl, and R. Ketting

Citation Count: 1
Published: 2025-12-21 in bioRxiv

Proton First: Rationalizing a Proton Transfer in a Protein‐Fragment Complex

Helge Vatheuer, Jonas Paulus, Lisa Johannknecht, G. Keller, Rebecca Maria Ziora, L. Stelzl, and P. Czodrowski

Citation Count: 1
Published: 2025-06-18 in Chemmedchem

Deciphering driving forces of biomolecular phase separation from simulations.

Lars V. Schäfer, and L. Stelzl

Citation Count: 18
Published: 2025-03-07 in Current opinion in structural biology

Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition

K. Gaurav, V. Busetto, D. J. Páez-Moscoso, Arya Changiarath, Sonya M. Hanson, Sebastian Falk, R. Ketting, and L. Stelzl

Citation Count: 4
Published: 2025-02-25 in Biophysical Journal

BPS2025 - Formation of micelles in IDPs: Insights from molecular simulations

Rodrigo F. Dillenburg, L. Stelzl, E. A. Lemke, and Martin Girard

Citation Count: 0
Published: 2025-02-01 in Biophysical Journal

Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning.

Arya Changiarath, Aayush Arya, Vasileios A. Xenidis, Jan Padeken, and L. Stelzl

Citation Count: 4
Published: 2024-09-25 in Faraday discussions

Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates

Emanuele Zippo, Dorothee Dormann, T. Speck, and L. Stelzl

Citation Count: 25
Published: 2024-09-14 in Nature Communications

Promoter and Gene-Body RNA-Polymerase II co-exist in partial demixed condensates Preprint

Arya Changiarath, D. Flores-Solis, J. J. Michels, Rosa Herrera Rodriguez, Sonya M. Hanson, Friederike Schmid, M. Zweckstetter, Jan Padeken, and L. Stelzl

Citation Count: 7
Published: 2024-06-21 in bioRxiv

Structure and internal dynamics of short RNA duplexes determined by a combination of pulsed EPR methods and MD simulations.

Maximilian Gauger, M. Heinz, Anna-Lena J. Halbritter, L. Stelzl, N. Erlenbach, Gerhard Hummer, S. T. Sigurdsson, and Thomas F. Prisner

Citation Count: 15
Published: 2024-03-26 in Angewandte Chemie

Condensate coexistence in gene transcription: Molecular dynamics insights

Arya Changiarath Sivadasan, L. Stelzl, and Jasper J. Michels

Citation Count: 0
Published: 2024-02-01 in Biophysical Journal

Liquid–Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics

Carola S. Krevert, Daniel Chávez, Sayantan Chatterjee, L. Stelzl, Sabine Pütz, Steven Joop Roeters, J. F. Rudzinski, N. L. Fawzi, Martin Girard, S. Parekh, and Johannes Hunger

Citation Count: 15
Published: 2023-12-06 in The Journal of Physical Chemistry Letters

Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

D. Flores-Solis, Irina P Lushpinskaia, Anton A. Polyansky, Arya Changiarath, M. Boehning, Milana Mirkovic, J. Walshe, Lisa M. Pietrek, P. Cramer, L. Stelzl, B. Žagrović, and M. Zweckstetter

Citation Count: 43
Published: 2023-09-25 in Nature Communications

Hierarchical Assembly of Single-Stranded RNA

Lisa M. Pietrek, L. Stelzl, and G. Hummer

Citation Count: 8
Published: 2023-09-23 in Journal of Chemical Theory and Computation

An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori

Alfred W. Bronkhorst, C. Y. Lee, M. Möckel, S. Ruegenberg, A. M. de Jesus Domingues, Shéraz Sadouki, Rossana Piccinno, Tetsutaro Sumiyoshi, M. Siomi, L. Stelzl, Katja Luck, and R. Ketting

Citation Count: 8
Published: 2023-04-03 in The EMBO Journal

From integrative atomic-resolution ensembles of disordered proteins to simulations of phase-separated condensates.

L. Stelzl, Lisa M. Pietrek, Xiao-Fei Ping, A. Holla, M. Sikora, J. Koefinger, D. Dormann, B. Schuler, M. Zweckstetter, and G. Hummer

Citation Count: 0
Published: 2023-02-01 in Biophysical journal

Single-chain and condensed-state behavior of hnRNPA1 from molecular simulations.

Jan Bauer, L. Stelzl, and Arash Nikoubashman

Citation Count: 2
Published: 2023-02-01 in Biophysical journal

Structural ensembles of disordered proteins from hierarchical chain growth and simulation.

Lisa M. Pietrek, L. Stelzl, and G. Hummer

Citation Count: 26
Published: 2022-10-28 in Current opinion in structural biology

Molecular determinants of dynamic protein-protein interactions in the functional cycle of the membrane protein DsbD Preprint

L. Stelzl, Paraskevi Kritsiligkou, A. Mehdipour, Andrew J. Baldwin, S. J. Ferguson, D. Mavridou, M. Sansom, and C. Redfield

Citation Count: 0
Published: 2022-09-07 in bioRxiv

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

S. Sekulovski, L. Sušac, L. Stelzl, R. Tampé, and S. Trowitzsch

Citation Count: 27
Published: 2022-09-03 in bioRxiv

Transition Rates and Efficiency of Collective Variables from Time-Dependent Biased Simulations.

Karen Palacio-Rodríguez, Hadrien Vroylandt, L. Stelzl, F. Pietrucci, G. Hummer, and Pilar Cossio

Citation Count: 28
Published: 2022-08-08 in The journal of physical chemistry letters

Substrate spectrum of PPM1D in the cellular response to DNA double-strand breaks

Justus F. Gräf, Ivan Mikicic, Xiao-Fei Ping, Claudia Scalera, Katharina Mayr, L. Stelzl, Petra Beli, and Sebastian A. Wagner

Citation Count: 11
Published: 2022-08-01 in iScience

Helical region near poly-Q tract in prion-like domain of Arabidopsis ELF3 plays role in temperature-sensing mechanism

Richard J. Lindsay, L. Stelzl, Lisa M. Pietrek, G. Hummer, P. Wigge, and Sonya M. Hanson

Citation Count: 2
Published: 2022-02-01 in Biophysical Journal

Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure

L. Stelzl, Lisa M. Pietrek, A. Holla, J. Oroz, M. Sikora, J. Köfinger, B. Schuler, M. Zweckstetter, and G. Hummer

Citation Count: 65
Published: 2021-11-24 in JACS Au

Transition rates, survival probabilities, and quality of bias from time-dependent biased simulations

Karen Palacio-Rodríguez, Hadrien Vroylandt, L. Stelzl, F. Pietrucci, G. Hummer, and Pilar Cossio

Citation Count: 3
Published: 2021-09-23 in Biophysical Journal

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation

Lara A. Gruijs da Silva, F. Simonetti, S. Hutten, H. Riemenschneider, Erin L. Sternburg, Lisa M. Pietrek, J. Gebel, V. Dötsch, D. Edbauer, G. Hummer, L. Stelzl, and D. Dormann

Citation Count: 182
Published: 2021-04-30 in The EMBO Journal

Simulation of FUS Protein Condensates with an Adapted Coarse-Grained Model

Zakarya Benayad, Sören von Bülow, L. Stelzl, and G. Hummer

Citation Count: 188
Published: 2020-10-10 in Journal of Chemical Theory and Computation

Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

L. Stelzl, D. Mavridou, E. Saridakis, Diego Gonzalez, Andrew J. Baldwin, S. J. Ferguson, M. Sansom, and C. Redfield

Citation Count: 13
Published: 2020-06-22 in eLife

Compaction of RNA Duplexes in the Cell

Alberto Collauto, Sören von Bülow, D. Gophane, S. Saha, L. Stelzl, G. Hummer, S. Sigurdsson, and T. Prisner

Citation Count: 33
Published: 2020-04-27 in Angewandte Chemie (International Ed. in English)

Hierarchical Ensembles of Intrinsically Disordered Proteins at Atomic Resolution in Molecular Dynamics Simulations

Lisa M. Pietrek, Lukas S. Stelzl, and Gerhard Hummer

Citation Count: 74
Published: 2019-12-06 in Journal of Chemical Theory and Computation

High-resolution EPR distance measurements on RNA and DNA with the non-covalent Ǵ spin label

M. Heinz, N. Erlenbach, L. Stelzl, Grace Thierolf, Nilesh R Kamble, S. Sigurdsson, T. Prisner, and G. Hummer

Citation Count: 28
Published: 2019-11-28 in Nucleic Acids Research

Local frustration determines loop opening in protein-protein association Preprint

L. Stelzl, D. Mavridou, E. Saridakis, Diego Gonzalez, Andrew J. Baldwin, S. J. Ferguson, M. Sansom, and C. Redfield

Citation Count: 0
Published: 2019-06-30 in bioRxiv

Efficient Ensemble Refinement by Reweighting

J. Köfinger, L. Stelzl, K. Reuter, César Allande, Katrin Reichel, and G. Hummer

Citation Count: 95
Published: 2018-12-18 in Journal of Chemical Theory and Computation

Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging.

Patrick Seyfried, M. Heinz, György Pinter, Dean-Paulos Klötzner, Yvonne Becker, M. Bolte, H. R. Jonker, L. Stelzl, G. Hummer, H. Schwalbe, and Alexander Heckel

Citation Count: 16
Published: 2018-11-05 in Chemistry

Dispersion Correction Alleviates Dye Stacking of Single-Stranded DNA and RNA in Simulations of Single-Molecule Fluorescence Experiments.

Kara K. Grotz, Mark F. Nueesch, Erik D. Holmstrom, M. Heinz, L. Stelzl, B. Schuler, and G. Hummer

Citation Count: 28
Published: 2018-10-04 in The journal of physical chemistry. B

Resolving the Conformational Dynamics of DNA with Ångstrom Resolution by Pulsed Electron-Electron Double Resonance and Molecular Dynamics.

L. Stelzl, N. Erlenbach, M. Heinz, T. Prisner, and G. Hummer

Citation Count: 37
Published: 2017-08-17 in Journal of the American Chemical Society

1H, 13C and 15N resonance assignments for the oxidized and reduced states of the N-terminal domain of DsbD from Escherichia coli

D. Mavridou, Lukas S. Stelzl, S. J. Ferguson, and C. Redfield

Citation Count: 4
Published: 2011-11-30 in Biomolecular Nmr Assignments